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Atzeyo’s core technology uses gold nanoparticles to
power photonic absorption biosensing for low cost, high sensitivity diagnostics.


Biosensors are analytic devices used to detect chemical substances, often biological in nature, with a physicochemical detector.

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Using gold nanotechnology, PRAM (Photonic Resonance Absorption Microscopy) provides recorded images allowing for both qualitative and quantitative results.


Atzeyo Biosensors merges many of the breakthrough biomarker detection concepts over the last few years into a single platform—PRAM combines the speed, simplicity, and affordability of a Point-of-Care device with the quality and accuracy of a core lab.
Unique breakthrough features include:

  • Portable

  • Detection of DNA, RNA, and protein biomarkers including revealing point mutations with unprecedented accuracy.

  • Multiplex capabilities

  • Qualitative and quantitative results

  • Sensitivity is better than PCR

  • Minimal sample prep for a range of sample types

  • Results within 30 minutes


The process has been validated in vitro with patient samples in liver, prostate, and lung cancers.

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Take an in-depth look at the PRAM technology.

Recent publications on the PRAM technology

  1. Nanoantenna-microcavity hybrids using highly cooperative plasmonic-photonic coupling, J.-N. Liu, Q. Huang, K.-K. Liu, S. Singamaneni, and B.T. Cunningham, Nano Letters, Vol, 17, No. 12,  pp. 7569–7577, 2017.​

  2. Detection and digital resolution counting of nanoparticles with optical resonators and applications in biosensing, M.A. Aguirre, K.D. Long, N. Li, S.L. Manoto, and B.T. Cunningham, Chemosensors (Invited Review), Vol. 6, No. 2, p. 13, 2018 doi:10.3390/chemosensors6020013.​

  3. Microcavity-Mediated Spectrally Tunable Amplification of Absorption in Plasmonic Nanoantennas, Q. Huang and B.T. Cunningham, Nano Letters, Vol. 19, No. 8, p. 5297-5303, 2019.​

  4. Digital-resolution detection of microRNA with single-base selectivity by photonic resonator absorption microscopy, T.D. Canady, N. Li, L.D. Smith, Y. Lu, M. Kohli, A.M. Smith, and B.T. Cunningham, Proceedings of the National Academy of Science,  Vol. 16, No. 39, p. 19362-19367, 2019.​

  5. Activate capture and digital counting (AC+DC) assay for protein biomarker detection integrated with a self-powered microfluidic cartridge, C. Che, N. Li, K.D. Long, M.A. Aguirre, T.D. Canady, Q. Huang, U. Demirci, and B.T. Cunningham, Lab on a Chip, Vol. 19, p. 3943-3953,  2020.  DOI: 10.1039/C9LC00728H, 2019.​

  6. Single-step, wash-free immunoassay for rapid quantitative analysis of serological antibody against SARS-CoV-2 by photonic resonator absorption microscopy, B. Zhao, C. Che, W. Wang, N. Li, and B.T. Cunningham, Talanta, Vol. 225, p. 122004, 2021.​

  7. A portable photonic resonator absorption microscope for point of care digital resolution nucleic acid molecular diagnostics, S. Ghosh, N. Li, Y. Xiong, Y.-G. Ju, M.P. Rathslag, E. Onal, E. Falkiewicz, M. Kohli, and B.T. Cunningham, Biomedical Optics Express, Vol. 12, No. 8, p. 4637-4650, 2021.​

  8. Digital-resolution and highly sensitive detection of multiple exosomal small RNAs by DNA toehold probe-based photonic resonator absorption microscopy, B. Zhao, W. Wang, N. Li, T. Garcia-Lezana, C.Che, X. Wang, A. Villanueva, B.T. Cunningham, Talanta, Vol. 241, p. 123256, 2022.​

  9. Accelerated digital biodetection using magneto-plasmonic nanoparticle-coupled photonic resonator absorption microscopy, C. Che, R. Xue, N. Li, P. Gupta, X. Wang, B. Zhao, S. Singamaneni, S. Nie, and B. T. Cunningham, ACS Nano, Vol. 16, No. 2, p. 2345-2354, 2022.​

  10. A target recycling amplification process for the digital detection of exosomal microRNAs through photonic resonator absorption microscopy, X. Wang, S. Shepherd, N. Li, C. Che, T. Song, Y. Xiong, I. Palm, B. Zhao, M. Kohli, U. Demirci, Y. Lu, B.T. Cunningham, Angewandte Chemie, 2023. In Print,

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